THE JOURNAL OF ANTIBIOTICS Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains
نویسندگان
چکیده
+ Institute of Organic Chemistry, Tammannstraße 2, D-37077 Göttingen, Germany ++ Division of Clinical Mycology, National Institute of Health, Department of Medical Science, Nonthaburi, Thailand +++ Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-City, Chiba (260), Japan ‡ Labor für Bodenmikrobiologie, Burggarten 9, D-35102 Lohra-Kirchvers, Germany ‡‡ Hans-Knöll-Institute of Natural Product Research e.V., Beutenbergstraße 11, D-07745 Jena, Germany
منابع مشابه
Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains.
New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3'-O-didemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against...
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تاریخ انتشار 2003